Hersh B, Dalmau J, Dangond F, Gultekin S, Geller E, Wen P Y
Division of Neurology, Brigham and Women's Hospital, Boston, MA 02115.
Neurology. 1994 Sep;44(9):1754-5. doi: 10.1212/wnl.44.9.1754.
We report a 74-year-old woman with opsoclonus, myoclonus, ataxia, and encephalopathy who had small-cell lung cancer and high titers of anti-Hu antibody in her serum. At autopsy, there were perivascular inflammatory infiltrates in the brainstem, putamen, and meninges overlying the orbital frontal cortex. Immunohistochemical studies showed the expression of the Hu antigens by the tumor and the presence of deposits of anti-Hu IgG in the patient's cortex, brainstem, and cerebellum, suggesting that anti-Hu immune response was related to the patient's clinical syndrome. This case of paraneoplastic opsoclonus, myoclonus, ataxia, and encephalopathy expands the spectrum of neurologic dysfunction associated with the anti-Hu antibody.
我们报告了一名74岁女性，患有眼阵挛、肌阵挛、共济失调和脑病，其血清中存在小细胞肺癌及高滴度抗Hu抗体。尸检时，在脑干、壳核以及眶额皮质上方的脑膜中有血管周围炎性浸润。免疫组织化学研究显示肿瘤表达Hu抗原，且患者皮质、脑干和小脑中存在抗Hu IgG沉积，提示抗Hu免疫反应与患者的临床综合征相关。这例副肿瘤性眼阵挛、肌阵挛、共济失调和脑病扩展了与抗Hu抗体相关的神经功能障碍谱。
