人类非小细胞肺癌中1号染色体1p32 - pter区域内两个持续缺失的区域。
Two consistently deleted regions within chromosome 1p32-pter in human non-small cell lung cancer.
作者信息
Chizhikov V, Zborovskaya I, Laktionov K, Delektorskaya V, Polotskii B, Tatosyan A, Gasparian A
机构信息
Oncogene Regulation Laboratory, NN Blokhin Cancer Research Center, Moscow, Russia.
出版信息
Mol Carcinog. 2001 Mar;30(3):151-8. doi: 10.1002/mc.1023.
Allelic losses at 1p32-pter have been reported as frequent events in human non-small cell lung cancer (NSCLC). To further characterize the region of deletions, we studied loss of heterozygosity on a panel of 102 microdissected NSCLC samples with 20 polymorphic markers spanning 1p32-pter. Two shortest regions of the overlap of the deletions (SROs) were found: SRO 2a (D1S417--D1S57) and SRO 2b (D1S450--D1S243). Allelic losses at either region correlated independently with advanced stage of disease and with postoperative metastasis and relapse (P < 0.05), suggesting that crucial genes in these regions are involved in NSCLC progression. Mol. Carcinog. 30:151--158, 2001.
1p32-pter的等位基因缺失在人类非小细胞肺癌（NSCLC）中被报道为常见事件。为进一步确定缺失区域的特征，我们使用跨越1p32-pter的20个多态性标记，对102个显微切割的NSCLC样本进行了杂合性缺失研究。发现了两个缺失重叠的最短区域（SROs）：SRO 2a（D1S417-D1S57）和SRO 2b（D1S450-D1S243）。任一区域的等位基因缺失均与疾病晚期、术后转移及复发独立相关（P < 0.05），提示这些区域的关键基因参与了NSCLC的进展。《分子致癌学》30:151-158，2001年。
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