性染色体与性别决定基因：有袋类动物和单孔目动物的启示

Sex chromosomes and sex-determining genes: insights from marsupials and monotremes.

作者信息

Pask A, Graves J A

机构信息

Department of Zoology, University of Melbourne, Parkville, Vic. 3052, Australia.

出版信息

EXS. 2001(91):71-95. doi: 10.1007/978-3-0348-7781-7_5.

DOI:10.1007/978-3-0348-7781-7_5

PMID:11301601

Abstract

Comparative studies of the genes involved in sex determination in the three extant classes of mammals, and other vertebrates, has allowed us to identify genes that are highly conserved in vertebrate sex determination and those that have recently evolved roles in one lineage. Analysis of the conservation and function of candidate sex determining genes in marsupials and monotremes has been crucial to our understanding of their function and positioning in a conserved mammalian sex-determining pathway, as well as their evolution. Here we review comparisons between genes in the sex-determining pathway in different vertebrates, and ask how these comparisons affect our views on the role of each gene in vertebrate sex determination.

摘要

对现存三类哺乳动物以及其他脊椎动物中参与性别决定的基因进行的比较研究，使我们能够识别出在脊椎动物性别决定中高度保守的基因，以及那些最近在一个谱系中演化出作用的基因。对有袋类动物和单孔目动物中候选性别决定基因的保守性和功能进行分析，对于我们理解它们在保守的哺乳动物性别决定途径中的功能和定位以及它们的进化至关重要。在这里，我们回顾了不同脊椎动物性别决定途径中基因之间的比较，并探讨这些比较如何影响我们对每个基因在脊椎动物性别决定中作用的看法。