Love R J, Philbey A W, Kirkland P D, Ross A D, Davis R J, Morrissey C, Daniels P W
Department of Veterinary Clinical Sciences, University of Sydney, Private Mail Bag 3, Camden, New South Wales 2570.
Aust Vet J. 2001 Mar;79(3):192-8. doi: 10.1111/j.1751-0813.2001.tb14578.x.
To describe a new syndrome characterised by embryonic mortalities, stillbirths, mummified foetuses and congenital malformations in a herd of intensively farmed pigs.
Field observations, laboratory investigations and examination of breeding records.
Pathology examinations were performed on mummified and congenitally deformed piglets during an outbreak of reproductive disease at a 2600 sow intensive piggery in New South Wales from April to October 1997. Reproductive performance was monitored during the outbreak and breeding records were examined retrospectively. Serum and tissue samples from pigs were tested for evidence of infection with known porcine pathogens and for a new virus, Menangle virus, isolated from stillborn piglets with deformities from the affected piggery in August 1997.
Reproductive disease occurred sequentially in all four breeding units at the affected piggery over a period of 21 weeks. The farrowing percentages in each unit decreased from 80 to 82% before the outbreak to 63 to 78% during the outbreak and the number of live piglets per litter declined from a mean of 9.6 to 9.8 before the outbreak to 7.2 to 8.9 during the outbreak. The proportion of affected litters (litters with less than six liveborn piglets) was highest (64%) in the sixth week of the outbreak. Mummified foetuses, stillborn piglets with arthrogryposis, craniofacial deformities and degeneration of the brain and spinal cord, were observed along with occasional abortions. Sera from sows that produced affected litters contained neutralising antibodies against Menangle virus and there was evidence that this virus had been introduced to the piggery in February 1997.
Reproductive disease in pigs due to Menangle virus was characterised by stillbirths, mummification, embryonic death and infertility, along with abortions, skeletal deformities and degeneration of the brain and spinal cord in affected foetuses and stillborn piglets.
描述一种新综合征，其特征为集约化养殖猪群中出现胚胎死亡、死胎、木乃伊化胎儿和先天性畸形。
实地观察、实验室调查及繁殖记录检查。
1997年4月至10月，在新南威尔士州一个拥有2600头母猪的集约化养猪场发生繁殖疾病暴发期间，对木乃伊化和先天性畸形仔猪进行了病理学检查。在暴发期间监测繁殖性能，并回顾性检查繁殖记录。检测了猪的血清和组织样本，以寻找感染已知猪病原体的证据，以及检测一种新病毒——梅南格病毒，该病毒于1997年8月从受影响猪场的畸形死胎仔猪中分离出来。
在21周的时间里，受影响猪场的所有四个繁殖单元依次发生了繁殖疾病。每个单元的产仔率从暴发前的80%至82%降至暴发期间的63%至78%，每窝活仔猪数量从暴发前的平均9.6至9.8头降至暴发期间的7.2至8.9头。在暴发的第六周，受影响窝数（活产仔猪少于6头的窝数）比例最高（64%）。观察到木乃伊化胎儿、患有关节弯曲、颅面畸形以及脑和脊髓退化的死胎仔猪，偶尔还有流产情况。产下受影响窝仔猪的母猪血清中含有针对梅南格病毒的中和抗体，且有证据表明该病毒于1997年2月被引入该猪场。
由梅南格病毒引起的猪繁殖疾病的特征为死胎、木乃伊化、胚胎死亡和不育，以及受影响胎儿和死胎仔猪出现流产、骨骼畸形和脑及脊髓退化。
