Fluge G, Stoa K F, Aarskog D
Acta Paediatr Scand. 1975 Mar;64(2):280-6. doi: 10.1111/j.1651-2227.1975.tb03835.x.
Thirty-seven cases of neonatal hypoglycaemia were studied at follow-up at the age of 2 6/12-r 9/12 years. Two of them had had hypoglycaemia were stuafter the newborn period, and another patient died in a hypoglycaemic state following surgery at 10 weeks of age. Twenty-three children had oral glucose tolerance tests and intravenous insulin tolerance tests performed. Diabetic glucose tolerance was noted in 3 children. None of them showed symptoms of diabetes mellitus, neither was there any family history of diabetes. One of these patients had experienced hypoglycaemia after the newborn period and responded with hyperinsulinism during the glucose tolerance test. The other hypoglycaemic patient showed an exaggerated insulin release in response to tolbutamide. Deficient serum cortisol response to insulin-induced hypoglycaemia was demonstrated in 7 patients and 6 of these had concomitant minimal growth hormone response. One of these patients also had a diabetic glucose tolerance. None were of short stature. It is probable that a disturbance in the hypothalamic-pituitary-adrenal axis may contribute to an impaired carbohydrate metabolism in some patients with neonatal hypoglycaemia.
对37例新生儿低血糖患儿进行了随访研究，随访年龄为2岁6个月至9岁。其中2例在新生儿期后仍有低血糖发作，另有1例患儿在10周龄手术时死于低血糖状态。对23名儿童进行了口服葡萄糖耐量试验和静脉胰岛素耐量试验。3名儿童出现糖尿病性糖耐量。他们均无糖尿病症状，也无糖尿病家族史。其中1例患者在新生儿期后经历过低血糖，在葡萄糖耐量试验中表现为高胰岛素血症。另1例低血糖患者对甲苯磺丁脲反应时胰岛素释放过度。7例患者血清皮质醇对胰岛素诱导的低血糖反应不足，其中6例同时伴有生长激素反应轻微。这些患者中1例也有糖尿病性糖耐量。无一例身材矮小。下丘脑 - 垂体 - 肾上腺轴功能紊乱可能在某些新生儿低血糖患者碳水化合物代谢受损中起作用。
