乙醇诱导的低血糖症中的葡萄糖周转率以及代谢和激素变化
Glucose turnover and metabolic and hormonal changes in ethanol-induced hypoglycaemia.
作者信息
Wilson N M, Brown P M, Juul S M, Prestwich S A, Sönksen P H
出版信息
Br Med J (Clin Res Ed). 1981 Mar 14;282(6267):849-53. doi: 10.1136/bmj.282.6267.849.
Abstract
Infusion of 67 g ethanol over four hours in fasted, non-obese normal men (a) induced hypoglycaemia by inhibiting gluconeogenesis; (b) produced noticeable increases in blood lactate, 3-hydroxybutyrate, and free fatty acid concentrations; (c) depressed plasma growth hormone concentrations, despite hypoglycaemia; and (d) raised plasma cortisol concentrations before significant hypoglycaemia occurred. These metabolic changes were explained by the reduction of redox state which accompanies ethanol oxidation. The pronounced changes in metabolic values recorded during this study suggested that the use of parenteral feeding regimens including ethanol needs to be reconsidered.
摘要
在禁食的非肥胖正常男性中，4小时内输注67克乙醇：(a) 通过抑制糖异生诱导低血糖；(b) 使血液中乳酸、3-羟基丁酸和游离脂肪酸浓度显著升高；(c) 尽管出现低血糖，但血浆生长激素浓度降低；(d) 在显著低血糖发生前血浆皮质醇浓度升高。这些代谢变化可通过乙醇氧化伴随的氧化还原状态降低来解释。本研究记录的代谢值的显著变化表明，需要重新考虑包括乙醇在内的肠外营养方案的使用。
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