Roupe G
Hudkliniken, Sahlgrenska Universitetssjukhuset, Göteborg.
Lakartidningen. 2001 Mar 7;98(10):1091-5.
Cutaneous aging includes true aging and photo-aging due to sun exposure. A decrease in epidermal turnover rate results in epidermal atrophy and delayed wound-healing. A reduction in the number of epidermal Langerhans' cells is responsible for a decrease in delayed immune responsiveness in skin observed in the elderly. Reduced numbers of fibroblasts and mast cells are typical histologic findings in aging human dermis. Collagen bundles become fragmented, less elastic and more brittle. Telomere shortening at the end of chromosomes is probably the major mechanism of cellular senescence in skin. Common skin tumors and other major age-related changes in the skin of the elderly are described.
皮肤老化包括自然老化和因日晒引起的光老化。表皮更替率降低会导致表皮萎缩和伤口愈合延迟。表皮朗格汉斯细胞数量减少是老年人皮肤中观察到的迟发性免疫反应性降低的原因。成纤维细胞和肥大细胞数量减少是老年人真皮老化的典型组织学表现。胶原束变得破碎、弹性降低且更易碎。染色体末端的端粒缩短可能是皮肤细胞衰老的主要机制。本文描述了老年人常见的皮肤肿瘤及皮肤其他主要的与年龄相关的变化。
