Legat Franz J, Wolf Peter
Research Unit for Photodermatology, Department of Dermatology, Medical University of Graz, Auenbruggerplatz 8, A-8036, Graz, Austria.
Photochem Photobiol Sci. 2006 Feb;5(2):170-6. doi: 10.1039/b508856a. Epub 2005 Nov 3.
Chronic exposure to ultraviolet radiation (UVR) plays a significant role in aging and carcinogenesis of the skin. Sensory nerve fibers densely innervate all layers of the skin and get in close anatomical as well as functional contact with cellular components of the epidermis and dermis. In this review, we address the impact of acute and chronic UVR exposure on the cutaneous sensory nervous system and its mediators. We suggest that skin cell-derived nerve growth factor (NGF) and skin nerve-derived neuropeptides such as substance P (SP) and calcitonin gene-related peptide (CGRP) may play a central role in intrinsic aging as well as extrinsic (photo-) aging of the skin. In addition, we discuss the possible role of these mediators in photocarcinogenesis.
长期暴露于紫外线辐射（UVR）在皮肤衰老和致癌过程中起着重要作用。感觉神经纤维密集地支配皮肤的所有层次，并在解剖学和功能上与表皮和真皮的细胞成分密切接触。在本综述中，我们探讨急性和长期UVR暴露对皮肤感觉神经系统及其介质的影响。我们认为，皮肤细胞衍生的神经生长因子（NGF）以及皮肤神经衍生的神经肽，如P物质（SP）和降钙素基因相关肽（CGRP），可能在皮肤的自然衰老以及外在（光）衰老中发挥核心作用。此外，我们还讨论了这些介质在光致癌作用中的可能作用。
