Cowan M J, Scher A M, Hildebrandt J
Am J Physiol. 1975 May;228(5):1568-74. doi: 10.1152/ajplegacy.1975.228.5.1568.
Heart rate response to electrical stimulation of the right stellate ganglion of vagotomized cats was studied before and after the administration of sodium pentobarbital. The increase and decrease of heart rate with the initiation and cessation of sympathetic stimulation could be accurately described by separate exponential time functions. The time constants of rise and decline, the maximum steady-state heart rate, and the time between cessation of stimulation and initial decrease of heart rate (lag) were functions of the frequency and voltage of stimulation. The main effects of sodium pentobarbital were: 1) to prolong the rise of heart rate by 20-30 percent (P smaller than 0.0001),2) to prolong the decay of heart rate by 36-56 percent (P smaller than 0.005), and 3) to decrease the resting heart rate. The effects were observed 10 min after administration of the drug and lasted at least 4 h.
在给迷走神经切断的猫注射戊巴比妥钠之前和之后，研究了其对右侧星状神经节电刺激的心率反应。交感神经刺激开始和停止时心率的增加和减少可以用单独的指数时间函数准确描述。上升和下降的时间常数、最大稳态心率以及刺激停止到心率开始下降之间的时间（滞后）是刺激频率和电压的函数。戊巴比妥钠的主要作用是：1）使心率上升时间延长20%-30%（P小于0.0001），2）使心率下降时间延长36%-56%（P小于0.005），3）降低静息心率。这些作用在给药10分钟后观察到，并至少持续4小时。
