Kittiniyom K, Gorse K M, Dalbegue F, Lichy J H, Taubenberger J K, Newsham I F
Department of Pathology, Virginia Commonweath University, Richmond, USA.
Breast Cancer Res. 2001;3(3):192-8. doi: 10.1186/bcr294. Epub 2001 Feb 12.
We examined the stage specificity and heterogeneity of 18p11 alterations in a series of tumors representing 96 microdissected samples. Significant loss of heterozygosity (LOH) (63%) was found, with 56% occurring early in ductal carcinoma in situ. Although most cases indicated LOH was clonally inherited, heterogeneity for 18p LOH occurred in 27% of tumors. When compared with other LOH data, 18p LOH was found in conjunction with allelic deletion on 3p, 9p, 17p and 17q, while 13q, 16q, and 11p were less frequently associated. These analyses suggest chromosome 18p11 alteration is a common and early event in breast disease.
我们检测了一系列肿瘤中18p11改变的阶段特异性和异质性，这些肿瘤代表了96个显微切割样本。发现显著的杂合性缺失（LOH）（63%），其中56%发生在导管原位癌的早期。虽然大多数病例表明LOH是克隆性遗传的，但27%的肿瘤中存在18p LOH的异质性。与其他LOH数据相比，18p LOH与3p、9p、17p和17q上的等位基因缺失同时出现，而13q、16q和11p与之关联较少。这些分析表明18号染色体p11改变是乳腺疾病中常见的早期事件。
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