Department of Neurological Surgery, Oregon Health & Science University, Portland, OR, USA.
J Neurooncol. 2010 Sep;99(3):315-24. doi: 10.1007/s11060-010-0381-8. Epub 2010 Sep 14.
In this article, we provide a brief description of the current understanding of aberrant signaling pathways in meningiomas. Cell signaling pathways are responsible for cellular differentiation, development, growth, growth inhibition, and death. In fact, signaling pathways can affect multiple intracellular functions, including those responsible for development, angiogenesis, and apoptosis. Ultimately, a further understanding of the signaling pathways involved in meningioma tumorigenesis will lead to the development and application of novel molecular treatments, such as small molecule inhibitors or interfering ribonucleic acid technologies.
在本文中，我们简要描述了目前对脑膜瘤异常信号通路的认识。细胞信号通路负责细胞的分化、发育、生长、生长抑制和死亡。事实上，信号通路可以影响多种细胞内功能，包括那些负责发育、血管生成和细胞凋亡的功能。最终，对脑膜瘤发生过程中涉及的信号通路的进一步了解将导致新型分子治疗方法的开发和应用，如小分子抑制剂或干扰 RNA 技术。
