产生白细胞介素-5的T细胞克隆和嗜酸性粒细胞增多患者的临床及免疫学特征

Clinical and immunological features of patients with interleukin-5-producing T cell clones and eosinophilia.

作者信息

Simon H U, Plötz S G, Simon D, Dummer R, Blaser K

机构信息

Department of Pharmacology, University of Bern, Switzerland.

出版信息

Int Arch Allergy Immunol. 2001 Jan-Mar;124(1-3):242-5. doi: 10.1159/000053723.

DOI:10.1159/000053723

PMID:11306981

Abstract

Recent work suggests that in some patients with the hypereosinophilic syndrome, a clone of abnormal T cells produces large amounts of interleukin-5. In this study, we examined 60 patients with idiopathic eosinophilia. Sixteen patients had circulating T cells with an aberrant immunophenotype that, in most cases, were associated with different forms of skin inflammation. The abnormal T cells produced large amounts of interleukin-5, which may have increased eosinophil differentiation in the bone marrow of these patients.

摘要

近期研究表明，在某些患有嗜酸性粒细胞增多综合征的患者中，异常T细胞克隆会产生大量白细胞介素-5。在本研究中，我们检查了60例特发性嗜酸性粒细胞增多症患者。16例患者的循环T细胞具有异常免疫表型，在大多数情况下，这与不同形式的皮肤炎症有关。异常T细胞产生大量白细胞介素-5，这可能增加了这些患者骨髓中嗜酸性粒细胞的分化。