Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
J Allergy Clin Immunol. 2010 Jul;126(1):3-13; quiz 14-5. doi: 10.1016/j.jaci.2010.01.055. Epub 2010 Apr 14.
Eosinophils are multifunctional leukocytes that increase in various tissues in patients with a variety of disorders. Locally, they can be involved in the initiation and propagation of diverse inflammatory responses. In this review the clinical association of eosinophils with diseases of the skin, lung, and gastrointestinal tract is summarized. An approach to determining the causal role of eosinophils in these diseases is presented. Recent findings concerning molecular diagnosis, cause, and treatment are discussed.
嗜酸性粒细胞是多功能白细胞,在患有各种疾病的患者的各种组织中增加。在局部,它们可以参与多种炎症反应的启动和传播。在这篇综述中,总结了嗜酸性粒细胞与皮肤、肺和胃肠道疾病的临床关联。提出了一种确定嗜酸性粒细胞在这些疾病中因果作用的方法。讨论了关于分子诊断、病因和治疗的最新发现。