Sim M F, Hopcroft R H
J Pharm Pharmacol. 1976 Aug;28(8):609-12. doi: 10.1111/j.2042-7158.1976.tb02810.x.
Diuretic effects of seven orally-acting diuretic agents have been examined in the mouse. The following compounds, examples of various types of orally active compound available, produced their characteristic diuretic effects: bendrofluazide, frusemide, ethacrynic acid, acetazolamide, triamterene, aminophylline and Su 15049A. The diuretic effects of the various agents were demonstrated under both water and saline-loading conditions. After allowing for differences in baseline sodium excretion, all diuretics except acetazolamide caused a further enhancement of sodium excretion after saline-loading compared with water-loading tests. The mouse possesses several advantages over the more commonly used rat since the range of diuretic responsiveness is greater. These results suggest that the mouse is a suitable species for diuretic testing.
已在小鼠中检测了七种口服利尿剂的利尿作用。以下化合物是各类可用口服活性化合物的示例，它们产生了各自的特征性利尿作用：苄氟噻嗪、呋塞米、依他尼酸、乙酰唑胺、氨苯蝶啶、氨茶碱和Su 15049A。在水负荷和盐负荷条件下均证实了各种药物的利尿作用。在考虑基线钠排泄差异后，与水负荷试验相比，除乙酰唑胺外，所有利尿剂在盐负荷后均导致钠排泄进一步增加。与更常用的大鼠相比，小鼠具有几个优势，因为其利尿反应范围更大。这些结果表明，小鼠是进行利尿剂测试的合适物种。
