一种在小鼠中筛选利尿剂的方法：对性别差异的研究。

A method for screening diuretic agents in the mouse: an investigation of sexual differences.

作者信息

Hill T W, Randall P J

出版信息

J Pharm Pharmacol. 1976 Jul;28(7):552-4. doi: 10.1111/j.2042-7158.1976.tb02793.x.

DOI:10.1111/j.2042-7158.1976.tb02793.x

Abstract

Acetazolamide, aminophyline, frusemide, ethacrynic acid and triamterene were tested for diuretic action at dosages of 3, 10 and 30 mg kg-1 (s.c.) in male and female mice. Each drug significantly raised sodium excretion and all but acetazolamide elevated urine volume and chloride excretion. Potassium excretion was significantly raised by acetazolamide and frusemide. Acetazolamide and triamterene evoked urinary alkalinization whereas frusemide and ethacrynic acid reduced urinary pH. Female mice were markedly more sensitive than males to the diuretic, natriuretic, chloruretic and urinary acidfying actions of ethacrynic acid.

摘要

对乙酰唑胺、氨茶碱、呋塞米、依他尼酸和氨苯蝶啶进行了测试，在雄性和雌性小鼠中以3、10和30mg kg-1（皮下注射）的剂量检测其利尿作用。每种药物均显著提高钠排泄量，除乙酰唑胺外，其他药物均增加尿量和氯排泄量。乙酰唑胺和呋塞米显著提高钾排泄量。乙酰唑胺和氨苯蝶啶引起尿液碱化，而呋塞米和依他尼酸降低尿液pH值。雌性小鼠对依他尼酸的利尿、利钠、利氯和尿液酸化作用明显比雄性小鼠更敏感。