Giachino A A, Rody K, Turek M A, Miller D R, Wherrett C, Moreau G, O'rourke K, Grabowski J, McLeish W, Fazekas A
Division of Orthopaedic Surgery, The Ottawa Hospital, General Campus, Ottawa, Ontario, Canada.
J Arthroplasty. 2001 Apr;16(3):288-92. doi: 10.1054/arth.2001.21457.
A double-blind, randomized, controlled study was undertaken to determine if a technique of intraoperative anticoagulation would decrease the incidence or severity of venous embolization after tourniquet release during total knee arthroplasty. Sixty-six patients were randomized to receive either the heparin or placebo treatment. Transesophageal echocardiography was performed before and after tourniquet release to detect embolic material in the right atrium. Transient opacification of the right atrium was observed in all patients within the first 30 seconds after tourniquet release. Regional limb heparinization is not effective in reducing the intensity of right atrium opacification because much of the echogenic material was composed of fat rather than thrombus.
进行了一项双盲、随机、对照研究，以确定一种术中抗凝技术是否会降低全膝关节置换术中止血带松开后静脉栓塞的发生率或严重程度。66名患者被随机分为接受肝素或安慰剂治疗。在止血带松开前后进行经食管超声心动图检查，以检测右心房中的栓子物质。在止血带松开后的前30秒内，所有患者均观察到右心房短暂性浑浊。局部肢体肝素化在降低右心房浑浊强度方面无效，因为大部分回声物质由脂肪而非血栓组成。
