Bacha E A, Almodovar M, Wessel D L, Zurakowski D, Mayer J E, Jonas R A, del Nido P J
Department of Cardiac Surgery, The Children's Hospital, Boston, Massachusetts, USA.
Ann Thorac Surg. 2001 Apr;71(4):1260-4. doi: 10.1016/s0003-4975(00)02664-3.
Low- and very low-birth weight infants are now candidates for reparative cardiac surgery. Outcomes after coarctation repair have not been characterized in this patient population.
We performed a retrospective review of 18 consecutive neonates less than 2 kg who underwent repair of aortic coarctation between August 1990 and December 1999.
Median weight was 1,330 g, and median gestational age was 31 weeks. A ventricular septal defect was present in 5 patients, and Shone's complex in 4. Sixteen patients had resection and end-to-end anastomosis, and 2 had resection and subclavian flap. Median clamp time was 15.5 minutes. One patient died during hospitalization. Two patients died late postoperatively (5-year estimated survival 80%). Mean follow-up was 28.5 months. Eight patients (44%) had a residual or recurrent coarctation, 5 underwent balloon dilation, and 3 underwent reoperation. Freedom from reintervention for recoarctation was 60% at 5 years. Shone's complex or a hypoplastic arch was an independent risk factor for decreased survival (p < 0.001). Very low birth weight was a multivariate predictor for increased risk of recoarctation (p = 0.01).
Coarctation repair in less than 2-kg premature non-Shone's infants can be performed with a low mortality. The rate of recoarctation is higher in the very low-birth weight infants, but can be managed with low risk.
低体重和极低体重的婴儿现在是心脏修复手术的候选对象。在这一患者群体中,主动脉缩窄修复术后的结果尚未得到描述。
我们对1990年8月至1999年12月期间连续18例体重小于2kg的新生儿进行了回顾性研究,这些新生儿均接受了主动脉缩窄修复术。
中位体重为1330g,中位胎龄为31周。5例患者存在室间隔缺损,4例存在Shone综合征。16例患者进行了切除和端端吻合,2例进行了切除和锁骨下皮瓣修复。中位阻断时间为15.5分钟。1例患者在住院期间死亡。2例患者术后晚期死亡(5年估计生存率80%)。平均随访时间为28.5个月。8例患者(44%)存在残余或复发性主动脉缩窄,5例接受了球囊扩张,3例接受了再次手术。5年时免于因再狭窄进行再次干预的比例为60%。Shone综合征或发育不全的主动脉弓是生存率降低的独立危险因素(p<0.001)。极低出生体重是再狭窄风险增加的多因素预测指标(p=0.01)。
体重小于2kg的非Shone综合征早产婴儿进行主动脉缩窄修复术的死亡率较低。极低体重婴儿的再狭窄发生率较高,但可通过低风险管理。