Kollmorgen G M, Sansing W A, Lehman A A, Fischer G, Longley R E, Alexander S S, King M M, McCay P B
Cancer Res. 1979 Sep;39(9):3458-62.
Concanavalin A-induced blastogenesis of spleen lymphocytes was significantly inhibited when lymphocytes from rats on a high-polyunsaturated-fat diet were compared to lymphocytes from rats on a low-fat diet. Responsiveness was dependent on source of serum since lymphocytes from rats fed a low-fat diet were suppressed in serum from rats fed a high-polyunsaturated-fat diet. Alternatively, lymphocytes from rats on a high-polyunsaturated-fat diet were more responsive in serum from low-fat-fed rats compared to their response in autologous serum. One of the inhibiting factors in serum was the lipoprotein fraction; however, rats on a high-polyunsaturated-fat diet probably had additional inhibitors in their serum. While tumor incidence was highest in rats with the least responsive lymphocytes was highest in rats with the least responsive lymphocytes and lowest in rats with the most responsive lymphocytes, the significance of the observation is not known.
将高多不饱和脂肪饮食大鼠的脾淋巴细胞与低脂饮食大鼠的淋巴细胞进行比较时，伴刀豆球蛋白A诱导的脾淋巴细胞增殖显著受到抑制。反应性取决于血清来源，因为低脂饮食大鼠的淋巴细胞在高多不饱和脂肪饮食大鼠的血清中受到抑制。相反，与在自身血清中的反应相比，高多不饱和脂肪饮食大鼠的淋巴细胞在低脂饮食大鼠的血清中反应更强。血清中的一种抑制因子是脂蛋白部分；然而，高多不饱和脂肪饮食大鼠的血清中可能还有其他抑制剂。淋巴细胞反应性最低的大鼠肿瘤发生率最高，而淋巴细胞反应性最高的大鼠肿瘤发生率最低，但这一观察结果的意义尚不清楚。
