吡唑呋喃单用及与三氟胸苷联合用于非霍奇金淋巴瘤的II期试验。
Phase II trial of pyrazofurin, alone and in combination with trifluorothymidine, in non-Hodgkin's lymphoma.
作者信息
Warrell R P, Currie V, Kempin S, Young C
出版信息
Cancer Treat Rep. 1979 Aug;63(8):1423-5.
PMID:113097
Abstract
A phase II trial of pyrazofurin, alone and in combination with trifluorothymidine, was carried out in patients with advanced non-Hodgkin's lymphoma. None of the 19 patients evaluable for response had complete or partial remissions but 14 had minor regressions. Toxicity, consisting primarily of myelosuppression and stomatitis, was of moderate severity. These studies suggest that pyrazofurin, alone or in combination with trifluorothymidine, is of limited utility in advanced non-Hodgkin's lymphoma.
摘要
对19例晚期非霍奇金淋巴瘤患者进行了嘌呤霉素单独及联合三氟胸苷的II期试验。在19例可评估疗效的患者中，无一例达到完全缓解或部分缓解，但有14例病情出现轻度缓解。毒性主要表现为骨髓抑制和口腔炎，严重程度为中度。这些研究表明，嘌呤霉素单独或联合三氟胸苷在晚期非霍奇金淋巴瘤中的应用价值有限。
相似文献
1
Phase II trial of pyrazofurin, alone and in combination with trifluorothymidine, in non-Hodgkin's lymphoma.吡唑呋喃单用及与三氟胸苷联合用于非霍奇金淋巴瘤的II期试验。
Cancer Treat Rep. 1979 Aug;63(8):1423-5.
2
Phase II trial of piperazinedione in Hodgkin's disease, non-Hodgkin's lymphoma, and multiple myeloma: a Southwest Oncology Group study.
Cancer Treat Rep. 1977 Dec;61(9):1617-21.
3
Phase II. Trial of 4'-(9-acridinylamino)methanesulfon-m-anisidide (AMSA) in the treatment of advanced non-Hodgkin's lymphoma.
Cancer Treat Rep. 1980 Oct-Nov;64(10-11):1157-8.
4
Clinical trial of weekly pyrazofurin.每周一次吡唑呋喃的临床试验。
Cancer Treat Rep. 1979 Aug;63(8):1363-5.
5
[Late phase II clinical study of amrubicin hydrochloride, a novel synthetic anthracycline derivative anticancer agent, for malignant lymphoma].
Gan To Kagaku Ryoho. 2001 Nov;28(12):1867-76.
6
7
Treatment of refractory acute nonlymphocytic leukemia with a combination of pyrazofurin and cytarabine.用吡唑呋喃菌素和阿糖胞苷联合治疗难治性急性非淋巴细胞白血病。
Cancer Treat Rep. 1982 Jun;66(6):1397-8.
8
cis-dichlorodiammineplatinum(II) with and without ICRF-159 in non-Hodgkin's lymphoma.
Cancer Treat Rep. 1980 Feb-Mar;64(2-3):301-4.
9
[Phase II study of KRN8602 (MX2) for malignant lymphoma].
Gan To Kagaku Ryoho. 1998 Jun;25(7):1001-6.
10
Phase II study of pyrazofurin in advanced colorectal carcinoma.吡唑呋喃用于晚期结直肠癌的II期研究。
Cancer Treat Rep. 1977 May-Jun;61(3):491-3.
引用本文的文献
1
Role of platelet-derived endothelial cell growth factor/thymidine phosphorylase in fluoropyrimidine sensitivity.血小板衍生内皮细胞生长因子/胸苷磷酸化酶在氟嘧啶敏感性中的作用。
Br J Cancer. 2003 Mar 24;88(6):957-64. doi: 10.1038/sj.bjc.6600808.
Zotero 插件