Nichols W C, Kvols L K, Ingle J N, Edmonson J H, Ahmann D L, Rubin J, O'Connell M J
Cancer Treat Rep. 1978 May;62(5):837-9.
The purpose of this phase II clinical trial was to evaluate the effectiveness of triazinate and pyrazofurin in the treatment of advanced breast cancer. Although an occasional patient experienced stability of disease, neither agent, as employed in this study, was able to produce an objective antitumor effect in this group of patients with previous chemotherapeutic exposure. At the dosages used in this study, neither agent can be recommended for further treatment of advanced breast cancer.
这项II期临床试验的目的是评估三嗪奈特和吡唑呋喃治疗晚期乳腺癌的有效性。尽管偶尔有患者病情稳定，但在本研究中使用的这两种药物，对于这群曾接受过化疗的患者，均未能产生客观的抗肿瘤效果。在本研究使用的剂量下，这两种药物均不推荐用于晚期乳腺癌的进一步治疗。
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