Malm A, Arborelius M, Lilja B, Gil R L, Bornmyr S
Cardiovasc Res. 1979 May;13(5):281-7. doi: 10.1093/cvr/13.5.281.
The effects on an acute myocardial infarction of equipotent hypotensive doses of nitroglycerin and dipyridamole were studied using the thermographic technique in open-chest dogs. Nitroglycerin did not reduce the cool ischaemic area in any of the nine dogs studied. In six of the dogs, in which the ischaemic region could be properly measured, the cool area slightly grew in size. Dipyridamole reduced the size of the ischaemic area in all the 20 dogs used. In the 19 in which the size could be adequately digitalised, the decrease in infarction size was statistically significant.
采用热成像技术,在开胸犬身上研究了等效降压剂量的硝酸甘油和双嘧达莫对急性心肌梗死的影响。在所研究的9只犬中,硝酸甘油未使任何一只犬的冷缺血面积缩小。在6只能够准确测量缺血区域的犬中,冷缺血面积略有增大。双嘧达莫使所有20只实验犬的缺血面积缩小。在19只能够进行充分数字化测量的犬中,梗死面积的减小具有统计学意义。