Takenaka F, Matuo M, Ishihara T
Arch Int Pharmacodyn Ther. 1975 Mar;214(1):75-85.
Effects of nitroglycerin, dipyridamole, adenosine, reactive hyperemia, propranolol, norepinephrine and sympathetic nerve stimulation on retrograde coronary blood flow were investigated in dogs with experimental coronary occlusion. The retrograde blood flow (RF), pressure and conductance of the occluded left anterior descending coronary artery were measured and compared with the flow (CF), pressure and conductance of the non-occluded circumflex artery. The RF increased during sympathetic nerve stimulation and after the administration of nitroglycerin and norepinephrine, while it decreased during reactive hyperemia and following injection of dipyridamole, adenosine and propranolol. The RF/CF ratio was increased by nitroglycerin and propranolol, whereas it was lowered by dipyridamole and adenosine. The results suggest that nitroglycerin and propranolol may produce a redistribution of myocardial blood flow and that the collateral vessels are little influenced by sympathetic nerve stimulation.
在实验性冠状动脉闭塞的犬中，研究了硝酸甘油、双嘧达莫、腺苷、反应性充血、普萘洛尔、去甲肾上腺素和交感神经刺激对逆行冠状动脉血流的影响。测量了闭塞的左前降支冠状动脉的逆行血流（RF）、压力和电导，并与非闭塞的回旋支动脉的血流（CF）、压力和电导进行比较。交感神经刺激期间以及给予硝酸甘油和去甲肾上腺素后，RF增加，而反应性充血期间以及注射双嘧达莫、腺苷和普萘洛尔后，RF降低。硝酸甘油和普萘洛尔使RF/CF比值升高，而双嘧达莫和腺苷则使其降低。结果表明，硝酸甘油和普萘洛尔可能会使心肌血流重新分布，且侧支血管受交感神经刺激的影响较小。
