Kikuyama S, Miyakawa M, Arai Y
Cell Tissue Res. 1979 Apr 30;198(1):27-33. doi: 10.1007/BF00234831.
The effect of thyroid hormone on the development of diencephalic monoaminergic neurons was studied in tadpoles of Bufo bufo japonicus. Monoamine-containing neurons in the preoptic recess organ (PRO) appeared later than those in the paraventricular organ (PVO) and nucleus infundibularis dorsalis (NID). After deprivation of thyroidal primordium no fluorescent neurons developed in the PRO. Development of monoaminergic neurons in the PVO and NID was not affected by thyroidectomy. Thyroxine treatment brought about the fluorescent neurons in the PRO of the thyroidectomized tadpoles. Fluorescent terminals in the median eminence became conspicuous around the capillaries which penetrated to the median emience, when the tadpoles reached late prometamorphic stage. In the median eminence of thyroidectomized tadpoles, the monoaminergic axon terminals did not develop. Thyroxine induced both the fluorescent terminals and the capillary penetration in the median eminence of the thyroidectomized tadpoles. In the tadpoles hypophysectomized at tail-bud stage, thyroxine induced neither the fluorescent terminals nor the capillaries in the median eminence.
在日本蟾蜍蝌蚪中研究了甲状腺激素对间脑单胺能神经元发育的影响。视前隐窝器官（PRO）中含单胺的神经元出现时间晚于室旁器官（PVO）和背侧漏斗核（NID）中的神经元。切除甲状腺原基后，PRO中未发育出荧光神经元。PVO和NID中单核胺能神经元的发育不受甲状腺切除术的影响。甲状腺素处理使甲状腺切除的蝌蚪的PRO中出现荧光神经元。当蝌蚪达到前变态晚期时，正中隆起处围绕穿透至正中隆起的毛细血管的荧光终末变得明显。在甲状腺切除的蝌蚪的正中隆起中，单胺能轴突终末未发育。甲状腺素诱导了甲状腺切除的蝌蚪的正中隆起中的荧光终末和毛细血管穿透。在尾芽期切除垂体的蝌蚪中，甲状腺素既未诱导正中隆起中的荧光终末也未诱导毛细血管。
