Lebedev S P, Potekaeva M A, Mukhin A S
Arkh Patol. 1975;37(2):54-62.
On the basis of morphological studies of 130 puncture material of the liver in 100 patients with chronic alcoholism the three morphological forms of its lesion were identified: dystrophic changes in hepacytes; alcoholic hepatitis (acute and chronic); cirrhosis of the liver. It is suggested that the morphological forms mentioned above represent the stages of one process--developing alcoholic hepatopathy. Progressing of the process in the liver in chronic alcoholism is connected with necroses of hepacytes as a result of toxic effect of alcohol with a subsequent reaction of the cells of the portal stroma and sinusoids. Gravity of lesions of the liver depends largerly on individual sensitivity to alcohol, one of the main factor of which may be the capacity of the liver to reproduce ADG.
基于对100例慢性酒精中毒患者的130份肝脏穿刺材料的形态学研究，确定了肝脏病变的三种形态学形式：肝细胞营养不良性改变；酒精性肝炎（急性和慢性）；肝硬化。上述形态学形式被认为是一个过程——酒精性肝病发展的阶段。慢性酒精中毒时肝脏病变的进展与酒精的毒性作用导致肝细胞坏死以及随后门静脉间质和血窦细胞的反应有关。肝脏病变的严重程度在很大程度上取决于个体对酒精的敏感性，其中一个主要因素可能是肝脏产生ADG的能力。
