[Morphogenesis of congestive fibrosis of the liver].

Genesis of the muscatel-like fibrosis of the liver was studied on section and experimental material. The methods of histological, histochemical and electron microscopy analysis were used. It was established that the rise of pressure in the system of hepatic veins in chronic cardiac decompensation was accompanied by drastic venous congestion, hemorrhages and necrosis of hepacytes in the circumference of the central and collecting veins and along the lines of their junction which resulted in inversion of the hepatic lobes. In the zones of venous congestion pericentral fibrosis developed, which occasionally may be accompanied by priportal fibrosis. At later stages, muscatel-like cirrhosis of the liver was formed. The latter was underlaid by an elevated tropocollagenous activity of cells, this activity apart from fibroplasts, may be fulfilled also by Dupffer's cells. In chronic hepatic congestion a number of compensatory-adaptive changes in the vessels may occur.