Huan V D, Ohtani K, Kasai R, Yamasaki K, Tuu N V
Institute of Pharmaceutical Sciences, Faculty of Medicine, Hiroshima University, Japan.
Chem Pharm Bull (Tokyo). 2001 Apr;49(4):453-60. doi: 10.1248/cpb.49.453.
An intensely sweet polyoxypregnane glycoside, telosmoside A15 (15), was isolated from an Asian Asclepiadaceae plant, Telosma procumbens, collected in Vietnam. This is the first time a sweet pregnane glycoside has been found, and its sweetness intensity is 1000 times greater than that of sucrose. From the same plant, 17 other new glycosides were isolated, having the same aglycone; they are named telosmosides A1-A14 (1-14) and A16-A18 (16-18). Some of these glycosides are also sweet, but others are tasteless or bitter. Chemical structures of the 18 glycosides were determined, and the structure-taste relationship was discussed.
从采自越南的亚洲萝藦科植物倒地铃（Telosma procumbens）中分离出一种甜度极高的多氧孕甾烷糖苷——telosmoside A15（15）。这是首次发现甜味孕甾烷糖苷，其甜度比蔗糖高1000倍。从同一植物中还分离出了另外17种新的糖苷，它们具有相同的苷元；分别命名为telosmosides A1 - A14（1 - 14）和A16 - A18（16 - 18）。其中一些糖苷也有甜味，但其他的无味或味苦。确定了这18种糖苷的化学结构，并讨论了结构与味道的关系。
