Powell J, Wojnarowska F
Department of Dermatology, Oxford Radcliffe Hospitals, Oxford, United Kingdom.
J Am Acad Dermatol. 2001 May;44(5):803-6. doi: 10.1067/mjd.2001.113474.
Lichen sclerosus (LS) of the vulva in children is presenting more commonly, but its origin is unknown.
The purpose of this study was to assess the prevalence of childhood vulvar LS, to examine factors that may play a role in its cause, and to attempt to define the current optimal treatment.
We surveyed 70 cases of LS currently being treated in the pediatric vulvar clinic to collect information on presentation, family history, associated disease, and typical course of the disorder. We looked retrospectively and prospectively at treatments for LS.
We found a prevalence of premenarchal LS of 1 in 900 and confirmed an increasing incidence. In a high proportion of cases (77%), the question of sexual abuse had been raised. A family history of LS was found in a minimum of 17% of cases. Associated autoimmune disease occurred in 14%, but 64% told of a family history, and atopy occurred in 59%. Potent topical steroid ointments appear to alleviate symptoms most effectively, with minimal side effects.
Although the cause of LS remains uncertain, it is not a rare disease in prepubertal girls. Current optimal management includes prompt diagnosis and institution of treatment with a potent topical steroid.
儿童外阴硬化性苔藓（LS）的发病率日益增高，但其病因尚不明确。
本研究旨在评估儿童外阴LS的患病率，探讨可能导致该病的因素，并尝试确定当前的最佳治疗方法。
我们对70例正在儿科外阴诊所接受治疗的LS患儿进行了调查，收集了关于临床表现、家族史、相关疾病以及该疾病典型病程的信息。我们回顾性和前瞻性地观察了LS的治疗方法。
我们发现青春期前LS的患病率为1/900，且发病率呈上升趋势。在很大一部分病例（77%）中，曾有人提出性虐待的问题。至少17%的病例有LS家族史。14%的病例伴有自身免疫性疾病，但64%的病例有家族病史，59%的病例有特应性。强效局部类固醇软膏似乎能最有效地缓解症状，且副作用最小。
尽管LS的病因仍不确定，但在青春期前女孩中并非罕见疾病。目前的最佳治疗方法包括及时诊断并使用强效局部类固醇进行治疗。
