Navarro E, Alonso S J, Trujillo J, Jorge E, Pérez C
Department of Pharmacology, University of La Laguna, Tenerife, Spain.
J Nat Prod. 2001 Jan;64(1):134-5. doi: 10.1021/np9904861.
Cytotoxicity, acute toxicity, and general pharmacological effects in mice of an arylnaphthalene lignan isolated from Jisticia hyssopifolia were studied. Elenoside was cytotoxic to human cancer cell lines in a range of concentrations from 10(-5) to 10(-4)M. It has an LD(50), ip in mice, of 305 mg/kg and central depressive properties at doses of 25, 50, and 100 mg/kg. Thus, elenoside appears to be a sedative with broad spectrum cytotoxicity.
对从水蓑衣（Jisticia hyssopifolia）中分离出的一种芳基萘木脂素在小鼠体内的细胞毒性、急性毒性和一般药理作用进行了研究。elenoside在10^(-5)至10^(-4)M的一系列浓度范围内对人类癌细胞系具有细胞毒性。它对小鼠腹腔注射的半数致死量（LD(50)）为305 mg/kg，在25、50和100 mg/kg剂量时具有中枢抑制特性。因此，elenoside似乎是一种具有广谱细胞毒性的镇静剂。
