来自台湾莲叶桐的细胞毒性木脂素。

Cytotoxic lignans from Formosan Hernandia nymphaeifolia.

作者信息

Chen I S, Chen J J, Duh C Y, Tsai I L

机构信息

Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical College, Taiwan, Republic of China.

出版信息

Phytochemistry. 1997 Jul;45(5):991-6. doi: 10.1016/s0031-9422(97)00064-2.

DOI:10.1016/s0031-9422(97)00064-2

PMID:9264609

Abstract

A new dibenzylbutyrolactone lignan, (--)-6-hydroxyyatein, along with two new furanoid lignans, (--)-hernone [(2R,3S,4R)-(--)-3-hydroxymethyl -4-(3",4",5"-trimethoxybenzoyl)-2-(3,4-dimethoxyphenyl) tetrahydrofuran] and (--)-nymphone [(2R,3S,4R)-(--)-3-hydroxymethyl-4-(3",4",5"-trimethoxybenzoyl)-2- (3,4-methylenedioxyphenyl)tetrahydrofuran], have been isolated and characterized from the trunk bark of Formosan Hernandia nymphaeifolia. The structures of these compounds were determined by means of spectral analyses. These three lignans exhibited cytotoxic activities against P-388, KB16, A549 and HT-29 cell lines.

摘要

从台湾莲叶桐的树干树皮中分离并鉴定出一种新的二苄基丁内酯木脂素（--）-6-羟基南烛木树脂酚，以及两种新的呋喃类木脂素（--）-赫诺内酯[（2R，3S，4R）-（--）-3-羟甲基-4-（3″，4″，5″-三甲氧基苯甲酰基）-2-（3，4-二甲氧基苯基）四氢呋喃]和（--）-nymphone[（2R，3S，4R）-（--）-3-羟甲基-4-（3″，4″，5″-三甲氧基苯甲酰基）-2-（3，4-亚甲二氧基苯基）四氢呋喃]。这些化合物的结构通过光谱分析确定。这三种木脂素对P-388、KB16、A549和HT-29细胞系表现出细胞毒性活性。