Wewetzer C, Jans T, Müller B, Neudörfl A, Bücherl U, Remschmidt H, Warnke A, Herpertz-Dahlmann B
Department of Child and Adolescent Psychiatry, University of Würzburg, Füchsleinstrasse 15, 97080 Würzburg, Germany.
Eur Child Adolesc Psychiatry. 2001 Mar;10(1):37-46. doi: 10.1007/s007870170045.
The aim of the catch-up follow-up study is to describe the long-term outcome of obsessive-compulsive disorder (OCD) with onset in childhood and adolescence. The psychiatric morbidity in adulthood including personality disorders was assessed and predictors in childhood for the course of obsessive-compulsive symptoms were examined. The total study group consisted of the entire patient population treated for OCD at our departments for child and adolescent psychiatry between 1980 and 1991. We reassessed 55 patients personally by way of structured interviews. The mean age of onset of OCD was 12.5 years and the mean follow-up time was 11.2 years. At the follow-up investigation 71% of the patients met the criteria for some form of psychiatric disorder, while 36% were still suffering from OCD. Of the patients with a present diagnosis of OCD 70% had at least one further clinical disorder (especially anxiety and affective disorders). The most frequent personality disorders diagnosed were obsessive-compulsive (25.5%), avoidant (21.8%), and paranoid (12.7%) personality disorders. In-patient treatment, terminating treatment against advice and tics in childhood or adolescence significantly correlated with more severe OC symptoms in adulthood.
这项追赶式随访研究的目的是描述童年和青少年期起病的强迫症（OCD）的长期转归。评估了成年期的精神疾病发病率，包括人格障碍，并研究了童年期强迫症症状病程的预测因素。整个研究组由1980年至1991年间在我们儿童和青少年精神科接受强迫症治疗的所有患者组成。我们通过结构化访谈对55名患者进行了亲自重新评估。强迫症的平均起病年龄为12.5岁，平均随访时间为11.2年。在随访调查中，71%的患者符合某种形式精神障碍的标准，而36%仍患有强迫症。目前诊断为强迫症的患者中，70%至少有一种其他临床疾病（尤其是焦虑症和情感障碍）。最常诊断出的人格障碍是强迫型（25.5%）、回避型（21.8%）和偏执型（12.7%）人格障碍。住院治疗、违背医嘱终止治疗以及童年或青少年期的抽动与成年期更严重的强迫症状显著相关。
