Ehrlich J R, Zhang G Q, Israel C W, Hohnloser S H
J. W.-Goethe-Universität, Frankfurt Medizinische Klinik IV Abteilung für Kardiologie Theodor-Stern-Kai 7 60599 Frankfurt/Main, Germany.
Z Kardiol. 2001 Mar;90(3):170-6. doi: 10.1007/s003920170180.
Signal averaging techniques are used for detection of low amplitude, high frequency signals in the surface ECG. P-wave signal-averaging has been used to predict the risk for development of atrial tachyarrhythmias in patients with structural heart disease. There is, however, a lack of prospective studies evaluating normal values of the P-wave signal-averaged ECG in healthy individuals. Moreover, day-to-day reproducibility of results of P-wave signal-averaging is not precisely known. Thus, the aim of this study was to determine normal values and reproducibility of time-domain P-wave signal-averaging in a large cohort of healthy volunteers. A commercially available device (MAC 5000, Marquette Hellige) was used for signal-averaging. A vector magnitude was calculated from Frank's orthogonal leads after P-waves were sampled and filtered with a spectral filter using fast fourier transform. We examined 123 volunteers without cardiovascular disease at two occasions. Mean P-wave duration was 114 +/- 13 ms for the overall study population. There was a slight but statistically significant increase in filtered P-wave duration with age (r = 0.32, p < 0.001). All values were reliably reproducible upon the second examination (r = 0.624 to 0.706, p < 0.0001). These results may serve as a future reference to other studies examining patients with structural heart disease.
信号平均技术用于检测体表心电图中的低振幅、高频信号。P波信号平均已被用于预测结构性心脏病患者发生房性快速心律失常的风险。然而，缺乏评估健康个体P波信号平均心电图正常值的前瞻性研究。此外，P波信号平均结果的日常可重复性尚不清楚。因此，本研究的目的是确定一大群健康志愿者时域P波信号平均的正常值和可重复性。使用市售设备（MAC 5000，Marquette Hellige）进行信号平均。在对P波进行采样并用快速傅里叶变换的频谱滤波器进行滤波后，根据Frank正交导联计算矢量大小。我们对123名无心血管疾病的志愿者进行了两次检查。整个研究人群的平均P波持续时间为114±13毫秒。随着年龄的增长，滤波后的P波持续时间有轻微但具有统计学意义的增加（r = 0.32，p < 0.001）。第二次检查时所有值均具有可靠的可重复性（r = 0.624至0.706，p < 0.0001）。这些结果可为其他研究结构性心脏病患者的研究提供未来参考。
