Militaru Constantin, Donoiu Ionut, Ionescu Dan-Dominic
University of Medicine and Pharmacy of Craiova, Craiova Cardiology Center, 1 Tabaci Street, Craiova, Romania.
Ann Noninvasive Electrocardiol. 2011 Oct;16(4):351-6. doi: 10.1111/j.1542-474X.2011.00462.x.
Signal-averaged electrocardiography of the P wave (P wave SAECG) is a noninvasive method for evaluating the risk of atrial fibrillation (AF). We aimed to study P wave SAECG parameters in a large number of apparently healthy subjects and to compare them with patients with converted AF.
We examined 591 individuals; P wave SAECG were recorded in 330 normal subjects, 31 patients with converted persistent AF and 57 patients with converted paroxysmal AF immediately after conversion, at 12 and 24 hours after conversion, then after 3 and 6 months. P wave SAECG were recorded using a commercially available machine aiming to obtain a noise level <1 μV.
In the normal population the duration of the filtered P wave (PWD) was higher in men. P wave duration, RMS(40) and RMS(30) were significantly correlated with age. By comparing the normal population with patients with persistent AF converted to sinus rhythm we demonstrated significant differences in PWD and P wave integral. Patients with recurrent persistent AF had significantly higher PWD. The study of patients with paroxysmal AF, compared to the control group, showed significant increase of the same parameters: PWD and integral of the P wave. Patients with recurrent paroxysmal AF had higher PWD and lower RMS(40) , RMS(30) , RMS(20) .
Filtered P wave duration was higher in men; PWD was weakly but significantly correlated with age. Patients with paroxysmal or persistent AF converted to sinus rhythm had significantly higher P wave duration and P wave integral.
P波信号平均心电图（P波SAECG）是一种评估房颤（AF）风险的非侵入性方法。我们旨在研究大量表面健康受试者的P波SAECG参数，并将其与房颤转复患者进行比较。
我们检查了591名个体；在330名正常受试者、31名持续性房颤转复患者和57名阵发性房颤转复患者转复后即刻、转复后12小时和24小时，以及3个月和6个月后记录P波SAECG。使用商用机器记录P波SAECG，目标是获得<1μV的噪声水平。
在正常人群中，男性的滤波P波持续时间（PWD）更高。P波持续时间、RMS(40)和RMS(30)与年龄显著相关。通过将正常人群与持续性房颤转复为窦性心律的患者进行比较，我们发现PWD和P波积分存在显著差异。复发性持续性房颤患者的PWD显著更高。与对照组相比，阵发性房颤患者的研究显示相同参数（PWD和P波积分）显著增加。复发性阵发性房颤患者的PWD更高，而RMS(40)、RMS(30)、RMS(20)更低。
男性的滤波P波持续时间更高；PWD与年龄呈弱但显著的相关性。阵发性或持续性房颤转复为窦性心律的患者的P波持续时间和P波积分显著更高。
