Walach H, Köster H, Hennig T, Haag G
Department of Environmental Medicine and Hygiene, University Hospital, Freiburg, Germany.
J Psychosom Res. 2001 Mar;50(3):155-60. doi: 10.1016/s0022-3999(00)00224-5.
The practice of homeopathy rests on symptoms, which have been produced by medicinal substances in healthy volunteers, often applied at ultramolecular dilutions. It is unknown whether these symptom patterns are due to specific effects or chance fluctuation.
We tested the hypothesis that a homeopathic substance can bring about symptoms different from observation and placebo in a double-blind, placebo-controlled crossover design with baseline observation.
87 out of 118 healthy volunteers took both placebo and homeopathic belladonna 30CH in random sequence, after a 2-week observation period, and finished the 8-week trial. Apart from an insignificant tendency for subjects to report more symptoms with belladonna (mean number: 27.34), as compared to observation (24.26) or placebo (24.17), there was no indication that subjects reacted differently to homeopathy than to placebo or during baseline.
There is no indication that belladonna 30CH produces symptoms different from placebo or from no intervention. Symptoms of a homeopathic pathogenetic trial (HPT) are most likely chance fluctuations.
顺势疗法基于健康志愿者服用药物（通常为超分子稀释剂）后产生的症状。目前尚不清楚这些症状模式是由于特定效应还是随机波动所致。
我们采用双盲、安慰剂对照交叉设计并进行基线观察，检验顺势疗法药物能否产生与观察和安慰剂不同的症状这一假设。
118名健康志愿者中有87人在经过2周观察期后，随机先后服用了安慰剂和顺势疗法的30CH颠茄制剂，并完成了为期8周的试验。与观察期（平均24.26个）或安慰剂组（平均24.17个）相比，受试者报告服用颠茄制剂后出现更多症状的倾向并不显著，没有迹象表明受试者对顺势疗法的反应与对安慰剂或基线期的反应不同。
没有迹象表明30CH颠茄制剂产生的症状与安慰剂或无干预情况不同。顺势疗法致病试验（HPT）的症状很可能是随机波动。
