囊性纤维化患者雾化吸入多黏菌素后出现支气管收缩。
Bronchoconstriction following nebulised colistin in cystic fibrosis.
作者信息
Cunningham S, Prasad A, Collyer L, Carr S, Lynn I B, Wallis C
机构信息
Portex Anaesthesia, Intensive Care and Respiratory Medicine, Great Ormond Street Hospital for Children, Great Ormond Street, London WC1N 3JH, UK.
出版信息
Arch Dis Child. 2001 May;84(5):432-3. doi: 10.1136/adc.84.5.432.
Abstract
Nebulised colistin is regularly used as antipseudomonal therapy in children with cystic fibrosis. We assessed bronchoconstriction in response to nebulised colistin in 58 children. Nebulised colistin significantly reduced FEV(1), MEF(25%), and SaO(2) for 15 minutes. In 20 children the reduction was greater than 10% from baseline FEV(1), and was still at that level in five at 30 minutes. Subjective assessment, baseline FEV(1), and serum IgE were unable to identify susceptible children. It is recommended that children receiving colistin should be carefully assessed for bronchoconstriction.
摘要
雾化多黏菌素常用于囊性纤维化患儿的抗假单胞菌治疗。我们评估了58名儿童雾化吸入多黏菌素后的支气管收缩情况。雾化多黏菌素使FEV(1)、MEF(25%)和SaO(2)在15分钟内显著降低。20名儿童的FEV(1)较基线下降超过10%，其中5名儿童在30分钟时仍处于该水平。主观评估、基线FEV(1)和血清IgE均无法识别易发生支气管收缩的儿童。建议对接受多黏菌素治疗的儿童进行支气管收缩情况的仔细评估。
相似文献
1
Bronchoconstriction following nebulised colistin in cystic fibrosis.囊性纤维化患者雾化吸入多黏菌素后出现支气管收缩。
Arch Dis Child. 2001 May;84(5):432-3. doi: 10.1136/adc.84.5.432.
2
Bronchial constriction and inhaled colistin in cystic fibrosis.支气管收缩与吸入性黏菌素在囊性纤维化中的应用
Chest. 2005 Feb;127(2):522-9. doi: 10.1378/chest.127.2.522.
3
A randomised clinical trial of nebulised tobramycin or colistin in cystic fibrosis.雾化妥布霉素或黏菌素治疗囊性纤维化的随机临床试验。
Eur Respir J. 2002 Sep;20(3):658-64. doi: 10.1183/09031936.02.00248102.
4
Effect of tonicity of nebulised colistin on chest tightness and pulmonary function in adults with cystic fibrosis.雾化多黏菌素的张力对成年囊性纤维化患者胸闷和肺功能的影响。
Thorax. 1997 Jul;52(7):656-8. doi: 10.1136/thx.52.7.656.
5
Dry powder inhalation of colistin in cystic fibrosis patients: a single dose pilot study.囊性纤维化患者吸入多黏菌素干粉：单剂量初步研究。
J Cyst Fibros. 2007 Jul;6(4):284-92. doi: 10.1016/j.jcf.2006.10.010. Epub 2006 Dec 20.
6
Nebulized colistin causes chest tightness in adults with cystic fibrosis.雾化吸入多黏菌素会导致成年囊性纤维化患者出现胸闷。
Respir Med. 1994 Feb;88(2):145-7. doi: 10.1016/0954-6111(94)90028-0.
7
Inhaled tobramycin and bronchial hyperactivity in cystic fibrosis.吸入用妥布霉素与囊性纤维化中的支气管高反应性
Pediatr Pulmonol. 2000 May;29(5):366-70. doi: 10.1002/(sici)1099-0496(200005)29:5<366::aid-ppul5>3.0.co;2-l.
8
Bronchial response to nebulized antibiotics in children with cystic fibrosis.囊性纤维化患儿对雾化抗生素的支气管反应。
Eur Respir J. 1990 Nov;3(10):1114-6.
9
Inhaled colistin for the treatment of tracheobronchitis and pneumonia in critically ill children without cystic fibrosis.吸入性黏菌素治疗重症儿童无囊性纤维化的气管支气管炎和肺炎。
Pediatr Pulmonol. 2010 Nov;45(11):1135-40. doi: 10.1002/ppul.21302.
10
Area under the maximum expiratory flow-volume curve--a sensitive parameter in the evaluation of airway patency.最大呼气流量-容积曲线下面积——评估气道通畅性的一个敏感参数。
Respiration. 2008;75(1):40-7. doi: 10.1159/000099615. Epub 2007 Feb 13.
引用本文的文献
1
Utilizing a three-dimensional printed additional nebulization chamber for colistin nebulization with a large diluent volume through a vibrating mesh nebulizer: proof of concept.利用三维打印的附加雾化腔通过振动网式雾化器进行大稀释体积的黏菌素雾化：概念验证
Eur Clin Respir J. 2025 Jul 11;12(1):2531615. doi: 10.1080/20018525.2025.2531615. eCollection 2025.
2
Polymyxin B and ethylenediaminetetraacetic acid act synergistically against and .多黏菌素 B 和乙二胺四乙酸对 和 具有协同作用。
Microbiol Spectr. 2024 Feb 6;12(2):e0170923. doi: 10.1128/spectrum.01709-23. Epub 2024 Jan 3.
3
Colistin Resistance in Molecular Mechanisms and Epidemiology.黏菌素耐药性的分子机制与流行病学
Antibiotics (Basel). 2023 Mar 4;12(3):516. doi: 10.3390/antibiotics12030516.
4
Causes of polymyxin treatment failure and new derivatives to fill the gap.多粘菌素治疗失败的原因及填补空白的新衍生物。
J Antibiot (Tokyo). 2022 Nov;75(11):593-609. doi: 10.1038/s41429-022-00561-3. Epub 2022 Sep 20.
5
Synchrotron-based X-ray fluorescence microscopy reveals accumulation of polymyxins in single human alveolar epithelial cells.基于同步加速器的X射线荧光显微镜揭示了多粘菌素在单个肺泡上皮细胞中的积累。
Antimicrob Agents Chemother. 2023 May 1;65(5). doi: 10.1128/AAC.02314-20. Epub 2021 Mar 1.
6
Rescuing the Last-Line Polymyxins: Achievements and Challenges.拯救最后一线多黏菌素：成就与挑战。
Pharmacol Rev. 2021 Apr;73(2):679-728. doi: 10.1124/pharmrev.120.000020.
7
A Breath of Fresh Air in the Fog of Antimicrobial Resistance: Inhaled Polymyxins for Gram-Negative Pneumonia.抗菌药物耐药阴霾中的一缕清新空气：吸入多粘菌素治疗革兰阴性菌肺炎
Antibiotics (Basel). 2019 Mar 16;8(1):27. doi: 10.3390/antibiotics8010027.
8
Inhaled Antimicrobials for Ventilator-Associated Pneumonia: Practical Aspects.吸入性抗生素治疗呼吸机相关性肺炎：实用方面。
Drugs. 2017 Sep;77(13):1399-1412. doi: 10.1007/s40265-017-0787-0.
9
Inhaled Antibiotic Therapy in Chronic Respiratory Diseases.慢性呼吸道疾病的吸入性抗生素治疗
Int J Mol Sci. 2017 May 16;18(5):1062. doi: 10.3390/ijms18051062.
10
Inhaled Antibiotics for Gram-Negative Respiratory Infections.用于革兰氏阴性菌呼吸道感染的吸入性抗生素
Clin Microbiol Rev. 2016 Jul;29(3):581-632. doi: 10.1128/CMR.00101-15.
本文引用的文献
1
Inhaled tobramycin and bronchial hyperactivity in cystic fibrosis.吸入用妥布霉素与囊性纤维化中的支气管高反应性
Pediatr Pulmonol. 2000 May;29(5):366-70. doi: 10.1002/(sici)1099-0496(200005)29:5<366::aid-ppul5>3.0.co;2-l.
2
Intermittent administration of inhaled tobramycin in patients with cystic fibrosis. Cystic Fibrosis Inhaled Tobramycin Study Group.囊性纤维化患者吸入妥布霉素的间歇性给药。囊性纤维化吸入妥布霉素研究组。
N Engl J Med. 1999 Jan 7;340(1):23-30. doi: 10.1056/NEJM199901073400104.
3
Effect of tonicity of nebulised colistin on chest tightness and pulmonary function in adults with cystic fibrosis.雾化多黏菌素的张力对成年囊性纤维化患者胸闷和肺功能的影响。
Thorax. 1997 Jul;52(7):656-8. doi: 10.1136/thx.52.7.656.
4
Nebulised antipseudomonal antibiotic therapy in cystic fibrosis: a meta-analysis of benefits and risks.囊性纤维化患者雾化抗假单胞菌抗生素治疗：效益与风险的荟萃分析
Thorax. 1996 Apr;51(4):364-8. doi: 10.1136/thx.51.4.364.
5
Bronchial response to nebulized antibiotics in children with cystic fibrosis.囊性纤维化患儿对雾化抗生素的支气管反应。
Eur Respir J. 1990 Nov;3(10):1114-6.
6
The functional development of the respiratory system from the period of gestation to adulthood.
Am Rev Respir Dis. 1979 Sep;120(3):625-95. doi: 10.1164/arrd.1979.120.3.625.
Zotero 插件