Parvanova V M, Pandova V V, Garanina Z M
National Oncological Center, Sofia.
Vopr Onkol. 2001;47(1):45-8.
A clinical trial was conducted at the Center's Clinic to compare breast conserving treatment (quandrantectomy + radiation) (BCT) with modified radical mastectomy (M). It included 190 patients with stage I-II carcinoma up to 30 mm (BCT with "negative margin"--122; M--68). All the patients had undergone full axillary dissection. Mean total dose of 48.8 Gy was delivered to the whole breast by means of an external beam. No boost to tumor bed was given. Forty-one percent of tumors in the mastectomy group were of medial or central localization. The locoregional recurrence rates were significantly different (BCT--4.09 vs. M--20.5%; p < 0.001). However, the differences between distant metastasis occurrence and 5-year survival were not (BCT--4.91 and 95.6%; M--11.76 and 91.8%; p > 0.5, respectively). Nor were they significant for the localization/5-year survival relationship: lateral breast tumor--92%, medial--100% and central--89% (p > 0.6).
在该中心的诊所进行了一项临床试验，以比较保乳治疗（象限切除术+放疗）（BCT）与改良根治性乳房切除术（M）。该试验纳入了190例I-II期癌灶最大径达30mm的患者（切缘阴性的BCT组——122例；M组——68例）。所有患者均接受了腋窝淋巴结清扫术。通过外照射对全乳给予的平均总剂量为48.8Gy。未对瘤床进行加量照射。乳房切除术组中41%的肿瘤位于内侧或中央。局部区域复发率存在显著差异（BCT组——4.09% 对比M组——20.5%；p<0.001）。然而，远处转移发生率和5年生存率之间的差异无统计学意义（BCT组——4.91%和95.6%；M组——11.76%和91.8%；p>0.5）。肿瘤位置/5年生存率关系的差异也无统计学意义：乳房外侧肿瘤——92%，内侧——100%，中央——89%（p>0.6）。
