Litviakov N V, Cherdyntseva N V, Beliavskaia V A, Malinovskaia E A, Il'inykh I S, Smol'ianinov E S
Research Institute of Oncology, Research Center, Russian Academy of Medical Science, Siberian Branch, Tomsk.
Vopr Onkol. 2001;47(1):86-9.
Course administration of the recombinant probiotic subalin was shown to significantly potentiate the cytotoxic action of macrophages from healthy and tumor-bearing mice against mastocytoma P-815 cells and syngeneic target cells of lung sarcoma of Lewis. Carrageenan, an inhibitor of macrophage activity, significantly cut down the antimetastaic effect of subalin. The crucial role of macrophages in the mechanism of this function of the drug is discussed.
重组益生菌subalin的疗程管理显示可显著增强健康小鼠和荷瘤小鼠巨噬细胞对肥大细胞瘤P - 815细胞以及Lewis肺癌肉瘤同基因靶细胞的细胞毒性作用。巨噬细胞活性抑制剂角叉菜胶显著降低了subalin的抗转移作用。文中讨论了巨噬细胞在该药物这一功能机制中的关键作用。
