Tran V T, LeHoang P, Herbort C P
Inflammatory Eye Diseases, La Source Eye Center, Lausanne, Switzerland.
Eye (Lond). 2001 Feb;15(Pt 1):23-30. doi: 10.1038/eye.2001.7.
To determine the use of high-frequency ultrasound biomicroscopy (UBM) in the assessment of inflammatory lesions of the iris, ciliary body, pars plana and peripheral vitreous, and in particular to determine the proportion of cases for which UBM contributed significant additional, hitherto inaccessible, information.
Charts of patients seen in the uveitis clinic at University Eye Hospital from November 1994 to September 1999 for whom a UBM investigation had been performed were analysed. UBM was performed in a standard manner, using a Humphrey UBM 840 system. The clinical relevance of the UBM findings was determined for the whole series and for the following six subgroups of patients arbitrarily established according to the type and location of pathology: hypotony, pseudophakic uveitis, iris and ciliary body pathology excluding hypotony, pars plana pathology, scleritis and Toxocara uveitis. Findings were classified as positive when they confirmed a suspected diagnosis of lesional process or when they gave essential information. Findings were classified as essential when they led to the diagnosis or when they modified therapeutic intervention.
During the study period 111 eyes of 77 patients were included. UBM findings contributed essential information that allowed a diagnosis to be reached or that influenced treatment in 43% of cases. It yielded positive findings in 91% of cases, enabling assessment of morphological changes in the iris, ciliary body, and retroiridal and peripheral vitreous induced by intraocular inflammatory or pseudo-inflammatory disorders. Specific UBM signs, present in all patients, were identified in Toxocara uveitis. The groups of patients that benefited most from UBM examination were those with hypotony (83% essential findings) and opaque media (100% essential findings).
For uveitis patients with an inflammatory process situated in the iris/ciliary body/pars plana/retroiridal vitreous areas, UBM was of great clinical value and improved the management in a significant manner.
确定高频超声生物显微镜（UBM）在评估虹膜、睫状体、睫状体平坦部和周边玻璃体炎性病变中的应用，尤其要确定UBM能提供重要的、此前无法获得的额外信息的病例比例。
分析1994年11月至1999年9月在大学眼科医院葡萄膜炎门诊就诊且接受了UBM检查的患者病历。使用汉弗莱UBM 840系统以标准方式进行UBM检查。确定了UBM检查结果对整个系列以及根据病理类型和位置任意划分的以下六个亚组患者的临床相关性：低眼压、人工晶状体眼葡萄膜炎、排除低眼压的虹膜和睫状体病变、睫状体平坦部病变、巩膜炎和弓蛔虫性葡萄膜炎。当检查结果证实了对病变过程的疑似诊断或提供了重要信息时，将其分类为阳性。当检查结果导致诊断或改变治疗干预时，将其分类为重要。
在研究期间，纳入了77例患者的111只眼。UBM检查结果在43%的病例中提供了能达成诊断或影响治疗的重要信息。在91%的病例中获得了阳性结果，从而能够评估眼内炎性或类炎性疾病引起的虹膜、睫状体以及虹膜后和周边玻璃体的形态变化。在弓蛔虫性葡萄膜炎中发现了所有患者都存在的特定UBM体征。从UBM检查中获益最大的患者组是低眼压患者（83%为重要检查结果）和屈光间质混浊患者（100%为重要检查结果）。
对于炎症位于虹膜/睫状体/睫状体平坦部/虹膜后玻璃体区域的葡萄膜炎患者，UBM具有重要的临床价值，并显著改善了治疗管理。
