Iurassich S, Trotta C, Palagiano A, Pace L
Clinica Dermosifilopatica, II Università degli Studi, Naples, Italy.
Minerva Ginecol. 2001 Apr;53(2):107-11.
In this paper we correlated the clinical severity of the polycystic ovary with the clinical manifestation of acne. Acne is an inflammatory process of follicle sebaceous unites. Polycystic ovaries (PCOS) are characterized by several subcapsular cystic follicles with an increased production of androgens. Onset of polycystic ovaries in women with acne, ranges from 45 to 84% of cases.
Sixty patients, aged from 19 to 28 years, with acne and polycystic ovaries were enrolled. The clinical severity of acne was appraised by millimetric macrophotography. This technique evaluated subsequent phases of acne like comedo, papules or pustules, nodular or scarring lesions. Polycystic ovaries were studied by ultrasound and hormonal assay. Sonora Logic 500 MD, by GE Echography, with 3.5 MHz convex probe, were employed. US examination was performed, in each patient, on day 6th, 10th, 15th and 22th of the menstrual cycle. The following US parameters were considered: dimension of the ovaries, thickness of albuginea and number of cysts. Serum levels of FSH, LH, 17-b-estradiol, progesterone, DHEA-S, testosterone and LH/FSH ratio were determined. Furthermore, the presence of premenstrual syndrome (PMS) was evaluated.
We found that in PCOS the increased levels of androgens can cause the onset of acne. Photographic score and ovaries ultrasonography may be useful in the assessment of the clinical association between acne and polycystic ovaries. We observed that the subsequent phases of acne were correlated with the clinical severity of polycystic ovaries and to the presence of Premenstrual Syndrome in 93% of the cases (56 of 60 patients).
US images, compared with visual score, established the clinical association between acne and PCOS in three phases with a progressive severity.
在本文中，我们将多囊卵巢的临床严重程度与痤疮的临床表现相关联。痤疮是毛囊皮脂腺单位的炎症过程。多囊卵巢（PCOS）的特征是多个包膜下囊性卵泡以及雄激素分泌增加。痤疮女性中多囊卵巢的发病率在45%至84%之间。
招募了60名年龄在19至28岁之间、患有痤疮和多囊卵巢的患者。通过毫米级宏观摄影评估痤疮的临床严重程度。该技术评估痤疮的后续阶段，如粉刺、丘疹或脓疱、结节性或瘢痕性病变。通过超声和激素测定研究多囊卵巢。使用GE超声的Sonora Logic 500 MD，配备3.5 MHz凸阵探头。在每个患者的月经周期第6天、第10天、第15天和第22天进行超声检查。考虑以下超声参数：卵巢大小、白膜厚度和囊肿数量。测定血清促卵泡生成素（FSH）、促黄体生成素（LH）、17-β-雌二醇、孕酮、硫酸脱氢表雄酮（DHEA-S）、睾酮和LH/FSH比值。此外，评估经前综合征（PMS）的存在情况。
我们发现，在多囊卵巢综合征中，雄激素水平升高可导致痤疮的发生。摄影评分和卵巢超声检查可能有助于评估痤疮与多囊卵巢之间的临床关联。我们观察到，痤疮的后续阶段与多囊卵巢的临床严重程度以及93%的病例（60例患者中的56例）经前综合征的存在相关。
与视觉评分相比，超声图像在三个严重程度逐渐增加的阶段确定了痤疮与多囊卵巢综合征之间的临床关联。
