Pavone P, Bianchini R, Trifiletti R R, Incorpora G, Pavone A, Parano E
Division of Pediatric Neurology, University of Catania, Italy.
Neurology. 2001 Apr 24;56(8):1047-51. doi: 10.1212/wnl.56.8.1047.
To define cognitive deficits in children with absence epilepsy.
Cognitive deficits have often been reported in children with epilepsy, but have rarely been characterized in patients with a specific epileptic syndrome.
Detailed neuropsychological testing was carried out on 16 right-handed children with absence epilepsy with similar clinical and EEG findings, and the findings were compared to 16 well-matched right-handed children without absence epilepsy.
The authors found lower scores of measures of general cognitive functioning and visuospatial skills in patients with absence epilepsy, as compared to controls. Memory disturbances were also detected in absence epilepsy patients, with selective involvement of nonverbal memory and delayed recall. In contrast, verbal memory and language skills were relatively preserved. Patients whose seizures began at an earlier age seemed to have more severe cognitive deficits.
Language skills tend to be relatively well preserved in children with generalized epilepsy, with more dysfunction seen in global terms rather than specific lateralizing deficits. Patients with absence epilepsy seem to show a similar neurocognitive profile that may be a reflection of the underlying epilepsy syndrome.
明确失神癫痫患儿的认知缺陷。
癫痫患儿常被报道存在认知缺陷，但在特定癫痫综合征患者中很少有特征描述。
对16名具有相似临床和脑电图表现的右利手失神癫痫患儿进行了详细的神经心理学测试，并将结果与16名匹配良好的无失神癫痫的右利手儿童进行比较。
作者发现，与对照组相比，失神癫痫患者的一般认知功能和视觉空间技能测量得分较低。在失神癫痫患者中也检测到记忆障碍，非言语记忆和延迟回忆有选择性受累。相比之下，言语记忆和语言技能相对保留。癫痫发作开始年龄较小的患者似乎有更严重的认知缺陷。
全身性癫痫患儿的语言技能往往相对保留较好，整体功能障碍比特定的定位缺陷更明显。失神癫痫患者似乎表现出类似的神经认知特征，这可能反映了潜在的癫痫综合征。
