Lane J M, Bora F W, Black J
Clin Orthop Relat Res. 1975(109):193-200. doi: 10.1097/00003086-197506000-00028.
Present surgical procedures for the repair of tendon injury are complicated by formation of peritendinous collagenous adhesions which restrict tendon gliding. Several sensitive biomechanical tests have been developed to quantitate peritendinous restriction of gliding. Using these tests it was found that cis-hydroxyproline significantly limits net collagen accumulation following tendon injury in a rat model and decreases the adhesive restraints to tendon gliding. cis-Hydroxyproline and other proline analoques offer a method for specifically preventing excessive collagen formation.
目前用于修复肌腱损伤的外科手术因腱周胶原粘连的形成而变得复杂，这种粘连会限制肌腱滑动。已经开发了几种敏感的生物力学测试来定量腱周滑动受限情况。通过这些测试发现，顺式羟脯氨酸在大鼠模型中可显著限制肌腱损伤后胶原的净积累，并减少对肌腱滑动的粘连限制。顺式羟脯氨酸和其他脯氨酸类似物提供了一种特异性防止胶原过度形成的方法。
