Speer D P, Feldman S, Chvapil M
J Surg Res. 1985 Mar;38(3):252-7. doi: 10.1016/0022-4804(85)90034-4.
The Lindsay chicken foot tendon model was utilized to test the effect of topically applied beta-aminopropionitrile base upon the tensile strength of peritendinous adhesions following tenolysis of a scarified flexor tendon. The agent reduced by one-third the force required to effect tendon gliding and flexion of the joints in the involved digit. The results show that topical beta-aminopropionitrile is effective in the control of peritendinous adhesions and, therefore, achieves sufficient depth of penetration topically to affect the peritendinous location. No adverse effects of the topically applied agent were demonstrated. The principle of topical therapeutics that may have significant benefits to patients with tendon injuries is demonstrated.
采用林赛鸡足肌腱模型，以测试局部应用β-氨基丙腈碱对瘢痕化屈肌腱松解术后腱周粘连抗张强度的影响。该药物使患指中实现肌腱滑动和关节屈曲所需的力减少了三分之一。结果表明，局部应用β-氨基丙腈可有效控制腱周粘连，因此，其局部渗透深度足以影响腱周部位。未发现局部应用该药物有不良反应。证明了局部治疗原则可能对肌腱损伤患者有显著益处。
