Braeckman B P, Houthoofd K, Vanfleteren J R
Department of Biology, Ghent University, Ledeganckstraat 35, B-9000, Ghent, Belgium.
Mech Ageing Dev. 2001 May 31;122(7):673-93. doi: 10.1016/s0047-6374(01)00222-6.
The nervous system acts as a major regulator of the life span of Caenorhabditis elegans. Temperature and chemical stimuli from the environment are integrated with internal signals from the reproductive system to specify adult longevity. An insulin-like signaling cascade acts in neurons and coordinates control of senescence of the entire organism by regulating metabolism and a stress response mechanism. Caloric restriction extends life span, possibly by activation of the stress response program.
神经系统是秀丽隐杆线虫寿命的主要调节者。来自环境的温度和化学刺激与来自生殖系统的内部信号整合在一起，以确定成虫的寿命。一种胰岛素样信号级联在神经元中起作用，并通过调节新陈代谢和应激反应机制来协调对整个生物体衰老的控制。热量限制可能通过激活应激反应程序来延长寿命。
