Fierro I M, Serhan C N
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Braz J Med Biol Res. 2001 May;34(5):555-66. doi: 10.1590/s0100-879x2001000500002.
Multicellular host responses to infection, injury or inflammatory stimuli lead to the formation of a broad range of chemical mediators by the host. The integrated response of the host is essential to health and disease; thus it is important to achieve a more complete understanding of the molecular and cellular events governing the formation and actions of endogenous mediators of resolution that appear to control the duration of inflammation. Lipoxins are trihydroxytetraene-containing lipid mediators that can be formed during cell-cell interactions and are predominantly counterregulators of some well-known mediators of inflammation. Since this circuit of lipoxin formation and action appears to be of physiological relevance for the resolution of inflammation, therapeutic modalities targeted at this system are likely to have fewer unwanted side effects than other candidates and current anti-inflammatory therapies. Here, we present an overview of the recent knowledge about the biosynthesis and bioactions of these anti-inflammatory lipid mediators.
多细胞宿主对感染、损伤或炎症刺激的反应会导致宿主产生多种化学介质。宿主的综合反应对健康和疾病至关重要；因此，更全面地了解控制内源性炎症消退介质形成和作用的分子和细胞事件非常重要，这些介质似乎能控制炎症的持续时间。脂氧素是一类含三羟基四烯的脂质介质，可在细胞间相互作用过程中形成，主要是一些知名炎症介质的反向调节因子。由于脂氧素形成和作用的这一过程似乎与炎症消退具有生理相关性，针对该系统的治疗方式可能比其他候选方法和当前的抗炎疗法产生更少的不良副作用。在此，我们概述了有关这些抗炎脂质介质生物合成和生物作用的最新知识。
