血脂异常在糖尿病视网膜病变中的作用。
The role of dyslipidemia in diabetic retinopathy.
作者信息
Hammer Sandra S, Busik Julia V
机构信息
Department of Physiology, Michigan State University, East Lansing, MI, United States.
Department of Physiology, Michigan State University, East Lansing, MI, United States.
出版信息
Vision Res. 2017 Oct;139:228-236. doi: 10.1016/j.visres.2017.04.010. Epub 2017 May 26.
Abstract
Diabetic retinopathy (DR) affects over 93million people worldwide and is the number one cause of blindness among working age adults. These indicators coupled with the projected rise of patients diagnosed with diabetes, makes DR a serious and prevalent vision threating disease. Data from recent clinical trials demonstrate that in addition to the well accepted role of hyperglycemia, dyslipidemia is an important, but often overlooked factor in the development of DR. The central aim of this review article is to showcase the critical role of dyslipidemia in DR progression as well as highlight novel therapeutic solutions that take advantage of the vital roles lipid metabolism plays in DR progression.
摘要
糖尿病视网膜病变（DR）在全球影响着超过9300万人，是工作年龄成年人失明的首要原因。这些指标加上预计糖尿病确诊患者数量的上升，使DR成为一种严重且普遍的视力威胁性疾病。近期临床试验数据表明，除了高血糖已被广泛认可的作用外，血脂异常是DR发生发展中的一个重要但常被忽视的因素。这篇综述文章的核心目的是展示血脂异常在DR进展中的关键作用，并强调利用脂质代谢在DR进展中所起的重要作用的新型治疗方案。
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