化学诱导的皮肤肿瘤在小鼠、大鼠和豚鼠同基因品系中的移植性。

Transplantability of chemically induced skin tumors in syngeneic strains of mice, rats, and guinea pigs.

作者信息

Räsänen O

出版信息

Exp Pathol (Jena). 1979;17(3):121-7. doi: 10.1016/s0014-4908(79)80018-6.

Abstract

Syngeneic tumour transplants to inbred female animal strains were carried out with basaliomas, squamous cell carcinomas and fibrosarcomas of the skin, induced by DMBA (9,10-dimethyl-1,2-benzanthracene) in the mouse, rat and guinea pig. A completely successful transplantation of all tumors was only achieved in the group of fibrosarcomas of the rat when a myocardial suspension of a young rat was used as a "supporting agent". This may be a new immuno-biological aspect in tumor transplantation. In the other groups, five tumors developed in the host animals after a period of latency of 10 months or more. Therefore, it is discussed whether two of these tumors grown in the host rats should be considered spontaneous. In addition I have found no earlier reports in the literature with successful DMBA-induced epidermal tumors transplantations in homologous or syngeneic animal strains. Tumors were grafted on to altogether 100 animals.

摘要

将由二甲基苯并蒽（9,10 - 二甲基 - 1,2 - 苯并蒽，DMBA）诱导产生的小鼠、大鼠和豚鼠皮肤基底细胞瘤、鳞状细胞癌和纤维肉瘤，移植到近交系雌性动物品系中。仅在大鼠纤维肉瘤组中，当使用幼鼠的心肌悬液作为“支持剂”时，所有肿瘤的移植才完全成功。这可能是肿瘤移植中一个新的免疫生物学方面。在其他组中，宿主动物在10个月或更长时间的潜伏期后出现了5个肿瘤。因此，讨论了宿主大鼠体内生长的这5个肿瘤中的2个是否应被视为自发肿瘤。此外，我在文献中未发现关于DMBA诱导的表皮肿瘤在同源或同基因动物品系中成功移植的早期报道。总共将肿瘤移植到了100只动物身上。