Stubbs R H, Haberman H H, Pawlowski A
Cancer Res. 1983 Sep;43(9):4448-53.
Junctional and compound pigmented nevi, induced by 9,10-dimethyl-1,2-benzanthracene in the skin of albino guinea pigs, were transplanted as split- and full-thickness grafts to athymic nude mice. This experiment was designed as a feasibility study to establish a model in which junctional nevi could be kept outside the donor organism for prolonged periods. Different methods of securing grafts and promoting their survival were used in 19 mice. Mice died or were killed between 15 and 178 days after grafting. Histology revealed that the grafts survived in 11 mice. Nevus cells were found in six mice. The time from grafting to the observation of nevus cells did not exceed 68 days. All nevi showed slight to advanced features of degeneration and disappearance. Poor survival of the guinea pig epidermal portion of the graft and a host cellular reaction appeared to be the main reasons why nevi had a tendency to disappear from the athymic nude mouse skin.
在白化豚鼠皮肤中由9,10 - 二甲基 - 1,2 - 苯并蒽诱导产生的交界性和复合性色素痣，作为分层皮片和全厚皮片移植到无胸腺裸鼠身上。本实验设计为一项可行性研究，旨在建立一个模型，使交界性痣能够在供体生物体外长期保存。对19只小鼠采用了不同的固定移植物和促进其存活的方法。小鼠在移植后15至178天之间死亡或被处死。组织学检查显示，11只小鼠的移植物存活。在6只小鼠中发现了痣细胞。从移植到观察到痣细胞的时间不超过68天。所有痣均呈现出轻微至严重的退化和消失特征。移植物中豚鼠表皮部分存活不佳以及宿主细胞反应似乎是痣倾向于从无胸腺裸鼠皮肤中消失的主要原因。
