Wang H, Zhu C B, Cao X D, Wu G C
State Key Laboratory of Neurobiology, Shanghai Medical University, Shanghai 200032.
Sheng Li Xue Bao. 1998 Jun;50(3):263-7.
Orphanin FQ (OFQ) is a newly-discovered neuropeptide which shares great similar sequence with endogenous opioid peptide but with different functions. The present study was to investigate the role of OFQ microinjected in the periaqueductal gray (PAG) on pain threshold and acupuncture analgesia (AA) using tail flick tests. The results show that the hyperalgesia of OFQ and its antagonization on AA in PAG are dose-related. OFQ in PAG decreases the enhancing effect on AA induced by ohmefentanyl, a selective mu-receptor agonist. These observations suggest that OFQ in PAG can increase the rat pain sensitivity and antagonize AA.
孤啡肽（OFQ）是一种新发现的神经肽，其与内源性阿片肽序列高度相似但功能不同。本研究旨在通过甩尾试验，探讨向中脑导水管周围灰质（PAG）微量注射孤啡肽对痛阈及针刺镇痛（AA）的作用。结果表明，PAG内孤啡肽引起的痛觉过敏及其对针刺镇痛的拮抗作用与剂量相关。PAG内孤啡肽可降低选择性μ受体激动剂奥芬太尼诱导的对针刺镇痛的增强作用。这些观察结果提示，PAG内孤啡肽可增加大鼠的疼痛敏感性并拮抗针刺镇痛。
