向大鼠中脑导水管周围灰质微量注射孤啡肽对脊髓背角广动力型神经元的影响。
Effects of microinjection of OFQ into PAG on spinal dorsal horn WDR neurons in rats.
作者信息
Yang Z L, Zhang Y Q, Wu G C
机构信息
State Key Laboratory of Medical Neurobiology, Department of Neurobiology, Shanghai Medical University, 138 Yi Xue Yuan Road, 200032, Shanghai, PR China.
出版信息
Brain Res. 2001 Jan 5;888(1):167-171. doi: 10.1016/s0006-8993(00)03100-0.
The aim of the present study was to examine the effect of microinjection of orphanin FQ (OFQ) into periaqueductal gray (PAG) on sensory processing in the wide dynamic range (WDR) neurons of the spinal dorsal horn and to explore the effect of OFQ on a descending system of pain modulation. The results show that microinjection of OFQ into ipsilateral PAG significantly facilitated C-fibre evoked response and post-discharge of spinal dorsal horn WDR neurons. This is consistent with our previous results obtained in behavioral studies. It suggests that the supraspinal effect of OFQ on pain may partly be mediated by PAG neurons.
本研究的目的是检测向中脑导水管周围灰质（PAG）微量注射孤啡肽（OFQ）对脊髓背角广动力范围（WDR）神经元感觉处理的影响，并探讨OFQ对下行性疼痛调制系统的作用。结果显示，向同侧PAG微量注射OFQ可显著促进脊髓背角WDR神经元的C纤维诱发反应和后放电。这与我们先前在行为学研究中获得的结果一致。提示OFQ对疼痛的脊髓上作用可能部分由PAG神经元介导。
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