Ettinger R A, Nepom G T
Virginia Mason Research Center and Department of Immunology, University of Washington School of Medicine, Seattle 98195-7710, USA.
Rev Immunogenet. 2000;2(1):88-94.
HLA-DQ alleles are strongly associated with IDDM susceptibility and protection. Studies assessing the molecular properties of HLA-DR, a HLA class II locus in linkage disequilibrium with HLA-DQ, have made substantial contributions toward elucidating the structure and function of HLA class II molecules. Reports on the molecular properties of HLA-DQ are now following and have revealed interesting observations regarding the stability of HLA-DQ alphabeta heterodimers. Future work is expected to provide an understanding of the mechanism by which HLA-DQ is associated with IDDM susceptibility and protection.
HLA - DQ等位基因与胰岛素依赖型糖尿病（IDDM）的易感性和保护性密切相关。HLA - DR是与HLA - DQ处于连锁不平衡状态的HLA II类基因座，评估其分子特性的研究为阐明HLA II类分子的结构和功能做出了重大贡献。关于HLA - DQ分子特性的报道也相继出现，并揭示了有关HLA - DQαβ异二聚体稳定性的有趣发现。预计未来的研究工作将有助于理解HLA - DQ与IDDM易感性和保护性相关的机制。
