与胰岛素依赖型糖尿病易感性相关的HLA DQα/β分子。HLA/自身免疫性疾病关联模型。
HLA DQ alpha/beta molecule associated with the susceptibility to insulin-dependent diabetes mellitus. A model for HLA/autoimmune disease association.
作者信息
Khalil I, Deschamps I, Lepage V, Morin L, Galibert F, Degos L, Hors J
机构信息
INSERM U93, Hôpital Saint-Louis, Paris, France.
出版信息
Nouv Rev Fr Hematol (1978). 1990;32(6):445-7.
We have proposed a molecular model of susceptibility to Insulin-Dependent Diabetes Mellitus (IDDM) based on the proportional expression at the cell surface of the following susceptible (S-S) HLA-DQ heterodimere composed of a chain DQ alpha Arg 52 positive (S) and a chain HLA-DQ beta Asp 57 negative (S). All other DQ alpha/beta chains associations are considered as protective molecules. This model allows a predictive scale of risk for the disease.
我们基于以下易感性（S-S）HLA-DQ异二聚体在细胞表面的比例表达，提出了胰岛素依赖型糖尿病（IDDM）易感性的分子模型，该异二聚体由一条DQα链精氨酸52阳性（S）和一条HLA-DQβ链天冬氨酸57阴性（S）组成。所有其他DQα/β链组合均被视为保护性分子。该模型可对疾病风险进行预测分级。
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